Peptides’ role in autism with emphasis on exorphins

Microbial Ecology in Health and Disease

关键词: autism;    peptides;    exorphins;    mass-spectroscopy;   

DOI  :  10.3402/mehd.v23i0.18958

来源: DOAJ

【 摘 要 】

Problem: The nature of the peptides found increased in urine from autism needs verification of their structure, especially those that show opioid activity. Methods: The peptides were separated on reverse phase C-18 HPLC in Trifluoroacetic acid–acetonitril gradients. Peaks eluting where synthetic opioids appear, and peaks that are common to most autistic children were analyzed by mass spectrometry and fragmentation pattern on a quadropole mass-spectrometer. Results: We could demonstrate exorphins in the urine from autistic children, and their length varied from one patient to the next. Conclusion: Exorphins are found in urine of autistic children and may account for their symptoms.

【 授权许可】

Unknown