Zebrafish-Based Screening Models for the Identification of Anti-Metastatic Drugs

Molecules

Joji Nakayama¹  Hideki Makinoshima² 

[1] Shonai Regional Industry Promotion Center, Tsuruoka, Yamagata, 997-0052, Japan;Tsuruoka Metabolomics Laboratory, National Cancer Center, Mizukami 246-2, Kakuganji, Tsuruoka, Yamagata 975-0052, Japan;

关键词: zebrafish;    metastasis;    EMT;    angiogenesis;    phenotyping screening;   

DOI  :  10.3390/molecules25102407

来源: DOAJ

【 摘 要 】

Metastasis, a leading contributor to the morbidity of cancer patients, occurs through a multi-step process: invasion, intravasation, extravasation, colonization, and metastatic tumor formation. Each process is not only promoted by cancer cells themselves but is also affected by their microenvironment. Given this complexity, drug discovery for anti-metastatic drugs must consider the interaction between cancer cells and their microenvironments. The zebrafish is a suitable vertebrate animal model for in vivo high-throughput screening studies with physiological relevance to humans. This review covers the zebrafish model used to identify anti-metastatic drugs.

【 授权许可】

Unknown