Palladium-catalyzed Sonogashira coupling reactions in γ-valerolactone-based ionic liquids

Beilstein Journal of Organic Chemistry

László T. Mika¹  József M. Tukacs²  László Orha²  László Kollár³ 

[1] Pécs, H-7624, Hungary;Department of Chemical and Environmental Process Engineering, Budapest University of Technology and Economics Műegyetem rkp. 3, Budapest, H-1111, Hungary;Department of Inorganic Chemistry, University of Pécs and János Szentágothai Research Center and MTA-PTE Research Group for Selective Chemical Syntheses, Ifjúság u. 6.;

关键词: catalysis;    cross coupling;    green chemistry;    ionic liquids;   

DOI  :  10.3762/bjoc.15.284

来源: DOAJ

【 摘 要 】

It was demonstrated that the γ-valerolactone-based ionic liquid, tetrabutylphosphonium 4-ethoxyvalerate as a partially bio-based solvent can be utilized as alternative reaction medium for copper- and auxiliary base-free Pd-catalyzed Sonogashira coupling reactions of aryl iodides and functionalized acetylenes under mild conditions. Twenty-two cross-coupling products were isolated with good to excellent yields (72–99%) and purity (>98%). These results represent an example which proves that biomass-derived safer solvents can be utilized efficiently in common, industrially important transformations exhibiting higher chemical and environmental efficiency.

【 授权许可】

Unknown