Synthesize and characterization of artificial human bone developed by using nanocomposite

EUREKA: Physics and Engineering

Nguyen Huu Phan¹  Do Ngoc Tu¹  Le Thi Phuong Thanh¹  Pham Van Dong¹  Shailesh S. Shirguppikar²  Santosh R. Patil²  Ngo Ngoc Vu³ 

[1] Hanoi University of Industry;Shivaji University, Kolhapur;Thai Nguyen University of Technology;

关键词: biocompatibility;    artificial bone;    hydroxyapatite;    biopolymers;    bioceramics;    cytotoxicity;   

DOI  :  10.21303/2461-4262.2022.002432

来源: DOAJ

【 摘 要 】

The combination of biopolymers with bioceramics plays vital role in development of artificial bone. Hydroxyapatite is extensively used as a material in prosthetic bone repair and replacement. In this paper synthesis of Hydroxyapatite- Polymethyl methacrylate – Zirconia (Hap-PMMA-ZrO2) composite by using powder metallurgy technique. The mechanical, morphological, In-vitro biocompatibility and tribological properties were characterized by universal testing machine, micro-vickers hardness tester, high resolution transmission electron microscope (HR-TEM), MTT assay and pin-on-disc setup. In-vitro cytotoxicity test on HeLa cell lines shows cell viability constant when doses concentration increases so material found non-toxic. Results show that micro Vickers hardness i.e. 520 approximately matches with natural human bone i.e. 400. Compressive strength is less as compared to human bone because of powder metallurgy route used for fabrication and is 74 MPa. Density of proposed composite artificial human bone i.e. 1.52 g/cc is less as compared to natural bone i.e. 2.90 g/cc. The Hap-PMMA-ZrO2 composite will be good biomaterials for bone repair and replacement work

【 授权许可】

Unknown