Providing Patients with Locally Advanced Cervical Cancer Access to Brachytherapy: Experience from a Referral Network for Women Treated in Overseas France

Cancers

Elie Rassy¹  Patricia Pautier¹  Sophie Espenel²  Eric Deutsch²  Rita Bentahila²  Cyrus Chargari²  Samir Achkar²  Sylvie Mengue³  Pierre Gustin³  Florence Sacino⁴  Alexis Vallard⁵  Vincent Vinh-Hung⁵  Stefanos Bougas⁵  Johan Encaoua⁶  Philippe Morice⁷  Sébastien Gouy⁷ 

[1] Medical Oncology Department, Gustave Roussy Cancer Campus, 94805 Villejuif, France;Radiation Oncology Department, Gustave Roussy Cancer Campus, 94805 Villejuif, France;Radiotherapy Department, Hospital Polynésie Française, 98714 Papeete, France;Radiotherapy Department, University Hospital of Guadeloupe, 97159 Pointe-à-Pitre, France;Radiotherapy Department, University Hospital of Martinique, 97200 Fort-de-France, France;Radiotherapy Department, University Hospital of Reunion Island, 97744 Saint-Denis, France;Surgical Oncology Department, Gustave Roussy Cancer Campus, 94805 Villejuif, France;

关键词: cervical cancer;    brachytherapy;    radiation oncology;    chemoradiation;   

DOI  :  10.3390/cancers14122935

来源: DOAJ

【 摘 要 】

Image-guided adaptive brachytherapy (IGABT) is part of the standard of care for locally advanced cervical cancer (LACC). Access to IGABT is limited in many regions, thus leading to treatment care disparities. We report the experience of a referral network for women with LACC between radiotherapy facilities in Overseas France and Gustave Roussy. This is a retrospective review of patients with LACC referred to Gustave Roussy, for pulsed-dose-rate (PDR) image-guided adaptive BT after initial radiation therapy in the French overseas between 2014 and 2021. Sixty-four patients were eligible to receive IGABT. Overall treatment time (OTT) was 60.5 days (IQR: 51–68.5). The median follow-up time was 17 months. At two years, estimated probabilities of LC, progression-free survival, and overall survival (OS) were 94.6% (95% CI: 88.9–100.0%), 72.7% (95% CI: 61.1–86.5%), and 82.5% (95% CI: 72.0–94.5%). In multivariable analysis, a D90CTVHR < 85GyEQD2 and a CTVHR volume > 40 cm³ were significant for poorer PFS (p = 0.001 and p = 0.009, respectively) and poorer OS (p = 0.004 and p = 0.004). The centralization of this advanced technique to expert centers requires a well-defined workflow and appropriate dimensioning of resources to minimize OTT.

【 授权许可】

Unknown