Roles of the Cell Surface Architecture of Bacteroides and Bifidobacterium in the Gut Colonization

Frontiers in Microbiology

Takao Mukai¹  Keita Nishiyama²  Tatsunari Yokoi³  Nobuhiko Okada³  Makoto Sugiyama⁴  Ro Osawa⁵ 

[1] Department of Animal Science, School of Veterinary Medicine, Kitasato University, Towada, Japan;Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan;Department of Microbiology, School of Pharmacy, Kitasato University, Tokyo, Japan;Laboratory of Veterinary Anatomy, School of Veterinary Medicine, Kitasato University, Towada, Japan;Research Center for Food Safety and Security, Kobe University, Kobe, Japan;

关键词: adhesion;    Bifidobacterium;    Bacteroides;    mucin;    mucosal bacteria;    cell surface protein;   

DOI  :  10.3389/fmicb.2021.754819

来源: DOAJ

【 摘 要 】

There are numerous bacteria reside within the mammalian gastrointestinal tract. Among the intestinal bacteria, Akkermansia, Bacteroides, Bifidobacterium, and Ruminococcus closely interact with the intestinal mucus layer and are, therefore, known as mucosal bacteria. Mucosal bacteria use host or dietary glycans for colonization via adhesion, allowing access to the carbon source that the host’s nutrients provide. Cell wall or membrane proteins, polysaccharides, and extracellular vesicles facilitate these mucosal bacteria-host interactions. Recent studies revealed that the physiological properties of Bacteroides and Bifidobacterium significantly change in the presence of co-existing symbiotic bacteria or markedly differ with the spatial distribution in the mucosal niche. These recently discovered strategic colonization processes are important for understanding the survival of bacteria in the gut. In this review, first, we introduce the experimental models used to study host-bacteria interactions, and then, we highlight the latest discoveries on the colonization properties of mucosal bacteria, focusing on the roles of the cell surface architecture regarding Bacteroides and Bifidobacterium.

【 授权许可】

Unknown