Surface Morphology and Histopathological Aspects of Metallic Used Cardiovascular CoCr Stents

Metals

George-Razvan Pandelea-Dobrovicescu¹  Florentina Golgovici¹  Mariana Prodana¹  Daniela Ionita¹  Ioana Demetrescu¹  Maria Sajin² 

[1] Department of General Chemistry, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Spl. Independentei 313, 060042 Bucharest, Romania;“Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu Street, 020021 Bucharest, Romania;

关键词: CoCr metallic stent;    surface analysis;    ion release;    histopathological analysis;    microcalcification;   

DOI  :  10.3390/met10091112

来源: DOAJ

【 摘 要 】

In this study, CoCr cardiovascular metallic stents with the same chemical composition as well as the adjacent tissues were analyzed. Recovered stents and adjacent tissues were characterized by surface morphology techniques like light microscopy (LM), scanning electron microscopy coupled with energy dispersive X-ray spectroscopy (SEM-EDS) and transmission electron microscopy (TEM). The presence of metals in the tissue from around explanted stent was also confirmed by TEM method. The released metal ions were measured using inductively coupled plasma mass spectrometry (ICP-MS). Histopathological analysis was used to highlight host tissue response to the implanted stents. EDX analysis revealed that 21 stents had the same composition. The quantities of Cr ions detected in the tissues were between 5 and 14 ppb and for Co ions were between 4 and 10 ppb. The tissue sections near the layers that generated large quantities of ions showed restenosis development and the deposits of surface calcifications were highlighted. The heavy metal levels observed in this study due to corrosion are too low to cause a systemic toxic response.

【 授权许可】

Unknown