CLINICAL PREDICTORS OF LOW BONE MINERAL DENSITY IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS

Остеопороз и остеопатии

M M Kostik¹  L A Scheplyagina²  V I Larionova³ 

[1] ГБОУВПО Санкт-Петербургский государственный педиатрический медицинский университет;Московский научно-исследовательский клинический институт им. М.Ф. Владимирского;Федеральное государственное бюджетное учреждение «Научно-исследовательский детский ортопедический институт им. Г. И. Турнера»;

关键词: ювенильный идиопатический артрит;    низкая минеральная плотность кости;    денситометрия;    воспаление;   

DOI  :  10.14341/osteo2014211-15

来源: DOAJ

【 摘 要 】

The aim of this study was to assess the role of simple clinical and laboratorial markers for prediction of low bone mineral density (LBMD < -2 SD) in children with juvenile idiopathic arthritis (JIA). Low weight and linear growth (<10% and 25%), BMI < 16.6, MD VAS > 5.0, DAS > 2.9, DAS28 > 4.2, JADAS 10 > 15.6, JADAS 27 > 15.1, CDAI > 18.1, Steinbrocker's functional class > 2, systemic arthritis, corticosteroid treatment, arthritis duration > 4.5 years, number of active joints > 5, number of painful joints > 9, morning stiffness > 90 minutes, parental overall JIA activity (VAS) > 5.8, ESR > 16 mm/h, CRP > 22.6 mg/l were associated with increased risk of LBMD in JIA children. Among metabolic markers Ca total < 2.42 mmol/l and Pi > 1.59 mmol/l also increased the possibility of LBMD. Our data can help to identify the JIA patients at risk for LBMD and to suggest the indications for densitometry evaluation of JIA children.

【 授权许可】

Unknown