Evidence of a Positive Link between Consumption and Supplementation of Ascorbic Acid and Bone Mineral Density

Nutrients

Simone Perna¹  Federica Fossari²  Viviana Vecchio²  Mara Nichetti²  MilenaAnna Faliva²  Maurizio Naso²  Gabriella Peroni²  Alice Tartara²  Enrica Di Paolo³  Mariangela Rondanelli⁴  Antonella Riva⁵  Giovanna Petrangolini⁵ 

[1] Department of Biology, College of Science, University of Bahrain, 32038 Sakhir, Bahrain;Endocrinology and Nutrition Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, University of Pavia, 27100 Pavia, Italy;General Geriatric Unit, Azienda di Servizi alla Persona “Istituto Santa Margherita”, 27100 Pavia, Italy;IRCCS Mondino Foundation, 27100 Pavia, Italy;Research and Development Department, Indena SpA, 20139 Milan, Italy;

关键词: ascorbic acid;    osteoporosis;    supplementation;    nutrients;    bone health;   

DOI  :  10.3390/nu13031012

来源: DOAJ

【 摘 要 】

In animal models it has been shown that ascorbic acid (AA) is an essential cofactor for the hydroxylation of proline in collagen synthesis. However, there are still no precise indications regarding the role of AA in maintaining bone health in humans, so the aim of this narrative review was to consider state of the art on correlation between bone mineral density (BMD), AA dietary intake and AA blood levels, and on the effectiveness of AA supplement in humans. This review included 25 eligible studies. Fifteen studies evaluated correlations between AA intake and BMD: eight studies demonstrated a positive correlation between AA dietary intake and BMD in 9664 menopausal women and one significant interaction between effects of AA intake and hormone therapy. These data were also confirmed starting from adolescence (14,566 subjects). Considering studies on AA blood concentration and BMD, there are four (337 patients) that confirm a positive correlation. Regarding studies on supplementation, there were six (2671 subjects), of which one was carried out with AA supplementation exclusively in 994 postmenopausal women with a daily average dose of 745 mg (average period: 12.4 years). BMD values were found to be approximately 3% higher in women who took supplements.

【 授权许可】

Unknown