Mitomycins syntheses: a recent update

Beilstein Journal of Organic Chemistry

Jean-Christophe Andrez¹ 

[1] Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T1Z1, Canada;

关键词: antitumour;    bioactivity;    mitomycin;    mitosene;    synthesis;   

DOI  :  10.3762/bjoc.5.33

来源: DOAJ

【 摘 要 】

Mitomycins are a class of very potent antibacterial and anti-cancer compounds having a broad activity against a range of tumours. They have been used in clinics since the 1960’s, and the challenges represented by their total synthesis have challenged generations of chemists. Despite these chemical and medicinal features, these compounds, in racemic form, have succumbed to total synthesis only four times over the last 30 years.

【 授权许可】

Unknown