IMMUNOINFLAMMATORY RHEUMATIC DISEASES ASSOCIATED WITH TYPE I INTERFERON: NEW EVIDENCE

Научно-практическая ревматология

A. S. Avdeeva¹  E. L. Nasonov² 

[1] I.M. Sechenov First Moscow State Medical University (Sechenov University);V.A. Nasonova Research Institute of Rheumatology;

关键词: immunoinflammatory rheumatic diseases;    type i interferons;    interferon signature;    systemic lupus erythematosus.;   

DOI  :  10.14412/1995-4484-2019-452-461

来源: DOAJ

【 摘 要 】

Immunoinflammatory rheumatic diseases (IIRDs) are a large group of pathological conditions with impaired immunological tolerance to autogenous tissues, leading to inflammation and irreversible organ damage. The review discusses current ideas on the role of type I interferons in the immunopathogenesis of IIRDs, primarily systemic lupus erythematosus, and new possibilities for personalized therapy.

【 授权许可】

Unknown