Anti-Cancer Activity of Phytochemicals Targeting Hypoxia-Inducible Factor-1 Alpha

International Journal of Molecular Sciences

Ba Da Yun¹  Jong Kook Park¹  Soo Young Choi¹  Seung Wan Son¹  Hyo Jeong Kuh²  Tae-Jin Oh³ 

[1] Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chunchon 24252, Korea;Department of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea;Department of Pharmaceutical Engineering and Biotechnology, SunMoon University, 70 Sunmoon-ro 221, Tangjeong-myeon, Asan-si 31460, Korea;

关键词: naturally derived compounds;    phytochemical;    hypoxia;    normoxia;    HIF;    cancer;   

DOI  :  10.3390/ijms22189819

来源: DOAJ

【 摘 要 】

Hypoxia-inducible factor-1 alpha (HIF-1α) is overexpressed in cancer, leading to a poor prognosis in patients. Diverse cellular factors are able to regulate HIF-1α expression in hypoxia and even in non-hypoxic conditions, affecting its progression and malignant characteristics by regulating the expression of the HIF-1α target genes that are involved in cell survival, angiogenesis, metabolism, therapeutic resistance, et cetera. Numerous studies have exhibited the anti-cancer effect of HIF-1α inhibition itself and the augmentation of anti-cancer treatment efficacy by interfering with HIF-1α-mediated signaling. The anti-cancer effect of plant-derived phytochemicals has been evaluated, and they have been found to possess significant therapeutic potentials against numerous cancer types. A better understanding of phytochemicals is indispensable for establishing advanced strategies for cancer therapy. This article reviews the anti-cancer effect of phytochemicals in connection with HIF-1α regulation.

【 授权许可】

Unknown