Cellular Senescence in Renal and Urinary Tract Disorders

Cells

Xavier Gamé¹  Pascal Rischmann¹  Jeanne Mialet-Perez²  Angelo Parini²  Yohan Santin²  Philippe Lluel³ 

[1] Department of Urology, Kidney Transplantation and Andrology, Toulouse Rangueil University Hospital, 31432 Toulouse, France;Institut des Maladies Métaboliques et Cardiovasculaires, Inserm, Université Paul Sabatier, UMR 1048—I2MC, 31432 Toulouse, France;Urosphere SAS, Rue des Satellites, 31400 Toulouse, France;

关键词: senescence;    aging;    SASP;    chronic kidney disease;    urogenital disorders;   

DOI  :  10.3390/cells9112420

来源: DOAJ

【 摘 要 】

Cellular senescence is a state of cell cycle arrest induced by repetitive cell mitoses or different stresses, which is implicated in various physiological or pathological processes. The beneficial or adverse effects of senescent cells depend on their transitory or persistent state. Transient senescence has major beneficial roles promoting successful post-injury repair and inhibiting malignant transformation. On the other hand, persistent accumulation of senescent cells has been associated with chronic diseases and age-related illnesses like renal/urinary tract disorders. The deleterious effects of persistent senescent cells have been related, in part, to their senescence-associated secretory phenotype (SASP) characterized by the release of a variety of factors responsible for chronic inflammation, extracellular matrix adverse remodeling, and fibrosis. Recently, an increase in senescent cell burden has been reported in renal, prostate, and bladder disorders. In this review, we will summarize the molecular mechanisms of senescence and their implication in renal and urinary tract diseases. We will also discuss the differential impacts of transient versus persistent status of cellular senescence, as well as the therapeutic potential of senescent cell targeting in these diseases.

【 授权许可】

Unknown