Synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives against HepG2 cell line

Open Chemistry

Fadlan Arif¹  Santoso Mardi¹  Rahmayanti Ardhana²  Fahmi Muhammad Riza Ghulam³ 

[1] Department of Chemistry, Faculty of Science, Institut Teknologi Sepuluh Nopember, Kampus ITS Sukolilo, Surabaya, 60111, Indonesia;Department of Environmental Engineering, Faculty of Engineering, Universitas Nahdlatul 10 Ulama Sidoarjo, Jl. Monginsidi Dalam KAV DPR, Sidoklumpuk, Sidoarjo, 61218, Indonesia;Ma Chung Research Center for Photosynthetic Pigments, Universitas Ma Chung, Villa Puncak Tidar N-01, Malang, 65151, Indonesia;

关键词: isatin;    isatin-pyrrole derivatives;    anticancer;    hepg2 cell line;   

DOI  :  10.1515/chem-2021-0023

来源: DOAJ

【 摘 要 】

This paper reports the synthesis and in vitro cytotoxicity evaluation of isatin-pyrrole derivatives 5–8, obtained from the appropriate isatins with pyrrole, with good yields and purity. The product structures were confirmed through spectroscopy methods. Furthermore, the MTT assay on the human liver cancer HepG2 cell lines revealed moderate activity in all compounds, which was highest in sample 6 (IC50 0.47 µM). The anticancer activity was affiliated with the presence of a nitro group at C-5 and N-methyl of the isatin scaffold.

【 授权许可】

Unknown