Metabolic Syndrome and Psoriasis: Mechanisms and Future Directions

Frontiers in Immunology

Zhen Wang¹  Ya-juan Zhu²  Song Zou³  Jiong Li⁵  Lin-na Gu⁶  Pei Zhou⁶  Qi-xiang Zhao⁶  Yan Hao⁶  Ya-wen Hu⁶  Hao-zhou Zhang⁶ 

[1] Liver Transplantation, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China;Department of Biotherapy and Cancer Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China;Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China;;Department of Liver Surgery &Laboratory of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China;State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu, China;

关键词: psoriasis;    metabolic syndrome;    gut microbiota;    insulin resistance;    autoimmunity;    obesity;   

DOI  :  10.3389/fimmu.2021.711060

来源: DOAJ

【 摘 要 】

Psoriasis is an immune-mediated systemic disease with associated comorbidities, including metabolic syndrome (MetS) which contributes substantially to premature mortality in patients with psoriasis. However, the pathological mechanisms underlying this comorbidity are unclear. Studies have shown that the pathological parameters of psoriasis mediate the development of MetS. We reviewed the potential mechanisms which mediate the association between psoriasis and MetS, including endoplasmic reticulum stress, pro-inflammatory cytokine releases, excess production of reactive oxygen species, alterations in adipocytokine levels and gut microbiota dysbiosis. Here, we highlight important research questions regarding this association and offer insights into MetS research and treatment.

【 授权许可】

Unknown