Genotype–phenotype associations of polymorphisms within the gene locus of NOD-like receptor pyrin domain containing 3 in Swiss inflammatory bowel disease patients

BMC Gastroenterology

Swiss IBD cohort study group¹  Yannick Franc²  Jean-Benoit Rossel²  Luc Biedermann³  Sebastian Bruno Ulrich Jordi³  Gerhard Rogler³  Benjamin Misselwitz³  Michael Scharl³  Martin Hausmann³  Isabelle Frey-Wagner³  Priyatharsan Yoganathan³ 

[1] ;Center for Primary Care and Public Health (Unisanté), University of Lausanne;Department of Gastroenterology and Hepatology, University Hospital and University of Zurich;

关键词: NLRP3 inflammasome;    Inflammatory bowel disease;    Single nucleotide polymorphisms;    Clinical characteristics;   

DOI  :  10.1186/s12876-021-01880-9

来源: DOAJ

【 摘 要 】

Abstract Background Genetic variations within the regulatory region of the gene encoding NOD-like receptor pyrin domain containing 3 (NLRP3) have been associated with Crohn’s Disease (CD). NLRP3 is part of the NLRP3-inflammasome that mediates the maturation of IL-1β and IL-18. Carrying the major allele of the single nucleotide polymorphisms (SNPs) rs10733113, rs4353135 and rs55646866 is associated with an increased risk for CD. We here studied the impact of these polymorphisms on clinical characteristics in patients of the Swiss IBD Cohort Study (SIBDCS). Methods We included 981 Crohn’s disease (CD) patients and 690 ulcerative colitis (UC) patients of the SIBDCS. We analyzed whether three CD-associated NLRP3 polymorphisms have an impact on the clinical disease course in these patients. Results In CD patients presence of the major allele (G) of rs10733113 was associated with less surgeries and lower maximal CDAI and a similar trend was observed for rs55646866 and rs4353135. Presence of the major allele of all three SNPs was negatively correlated to maximal CDAI. In UC patients homozygous genotype for the major allele (CC) for rs55646866 was associated with a higher age at diagnosis and a higher MTWAI index. Homozygous genotype for the major allele of all three polymorphisms was associated with a higher number of ambulatory visits and longer hospital stays. Conclusions In CD patients presence of the major allele of all three polymorphisms was associated with markers of a less severe disease course, while in UC the homozygous genotype for all major alleles suggested a more severe disease activity.

【 授权许可】

Unknown