GSK-3β, a pivotal kinase in Alzheimer disease

Frontiers in Molecular Neuroscience

Jesus eAvila¹  Felix eHernandez¹  Jeronimo eJurado¹  Maria eLLorens-Martin¹ 

[1]CIBERNED

[2]Centro de Biología Molecular Severo Ochoa (CSIC-­UAM)

关键词: Alzheimer Disease;    tau Proteins;    neurodegeneration;    kinase;    GSK3b;   

DOI  :  10.3389/fnmol.2014.00046

来源: DOAJ

【 摘 要 】

Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of AD is considered to be multifactorial as only a negligible percentage of cases have a familial or genetic origin. Glycogen synthase kinase-3 (GSK-3) is regarded as a critical molecular link between the two histopathological hallmarks of the disease, namely senile plaques and neurofibrillary tangles. In this review, we summarize current data regarding the involvement of this kinase in several aspects of AD development and progression, as well as key observations highlighting GSK-3 as one of the most relevant targets for AD treatment.

【 授权许可】

Unknown