Radiomics Analysis of Contrast-Enhanced CT for the Preoperative Prediction of Microvascular Invasion in Mass-Forming Intrahepatic Cholangiocarcinoma

Frontiers in Oncology

Xingyu Liu¹  Xiaoyuan Liang¹  Fei Xiang¹  Sheng Yan¹  Shumei Wei²  Lili Yang³ 

[1] Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Pathology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Radiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;

关键词: intrahepatic cholangiocarcinoma;    microvascular invasion;    radiomics;    computed tomography;    nomogram;   

DOI  :  10.3389/fonc.2021.774117

来源: DOAJ

【 摘 要 】

BackgroundMicrovascular invasion (MVI) has been shown to be closely associated with postoperative recurrence and metastasis in patients with intrahepatic cholangiocarcinoma (ICC). We aimed to develop a radiomics prediction model based on contrast-enhanced CT (CECT) to distinguish MVI in patients with mass-forming ICC.Methods157 patients were included and randomly divided into training (n=110) and test (n=47) datasets. Radiomic signatures were built based on the recursive feature elimination support vector machine (Rfe-SVM) algorithm. Significant clinical-radiologic factors were screened, and a clinical model was built by multivariate logistic regression. A nomogram was developed by integrating radiomics signature and the significant clinical risk factors.ResultsThe portal phase image radiomics signature with 6 features was constructed and provided an area under the receiver operating characteristic curve (AUC) of 0.804 in the training and 0.769 in the test datasets. Three significant predictors, including satellite nodules (odds ratio [OR]=13.73), arterial hypo-enhancement (OR=4.31), and tumor contour (OR=4.99), were identified by multivariate analysis. The clinical model using these predictors exhibited an AUC of 0.822 in the training and 0.756 in the test datasets. The nomogram combining significant clinical factors and radiomics signature achieved satisfactory prediction efficacy, showing an AUC of 0.886 in the training and 0.80 in the test datasets.ConclusionsBoth CECT radiomics analysis and radiologic factors have the potential for MVI prediction in mass-forming ICC patients. The nomogram can further improve the prediction efficacy.

【 授权许可】

Unknown