The neural substrate of prior information in perceptual decision making: a model-based analysis

Frontiers in Human Neuroscience

Jane Neumann¹  Eric-Jan Wagenmakers²  Birte U Forstmann²  Gilles Dutilh²  Scott Brown³ 

[1] Max Planck Institute for Human Cognitive and Brain Sciences;University of Amsterdam;University of Newcastle;

关键词: Putamen;    orbitofrontal cortex;    Response bias;    model-based fMRI;    cortico-striatal circuit;    response time modeling;   

DOI  :  10.3389/fnhum.2010.00040

来源: DOAJ

【 摘 要 】

Prior information biases the decision process: actions consistent with prior information are executed swiftly, whereas actions inconsistent with prior information are executed slowly. How is this bias implemented in the brain? To address this question we conducted an experiment in which people had to decide quickly whether a cloud of dots moved coherently to the left or to the right. Cues provided probabilistic information about the upcoming stimulus. Behavioral data were analyzed with the linear ballistic accumulator (LBA) model, confirming that people used the cue to bias their decisions. The fMRI data showed that presentation of the cue differentially activated orbitofrontal cortex, hippocampus, and the putamen. Directional cues selectively activated the contralateral putamen. The fMRI analysis yielded results only when the LBA bias parameter was included as a covariate, highlighting the practical benefits of formal modeling. Our results suggest that the human brain uses prior information by increasing cortico-striatal activation to selectively disinhibit preferred responses.

【 授权许可】

Unknown