Pterostilbene Prevents Early Diabetic Retinopathy Alterations in a Rabbit Experimental Model

Nutrients

Maríadel Carmen Desco¹  Jorge Mataix¹  Miguel Asensi²  Inés Pulido²  Salvador Pérez²  ÁngelLuis Ortega²  Salvador Mena-Mollá²  Iván Millán³  Isabel Torres-Cuevas³ 

[1] FISABIO Oftalmología Médica, Vitreo-retina unit, Bif. Pío Baroja General Avilés s/n, 46015 Valencia, Spain;Faculty of Pharmacy, Department of Physiology, University of Valencia, Vicente Andrés Estellés Av. s/n, 46100 Burjassot, Spain;Health Research Institute La Fe, Neonatal Research Group, Av. Fernando Abril Martorell 106, 46026 Valencia, Spain;

关键词: diabetic retinopathy;    polyphenol;    pterostilbene;    oxidative stress;    retinal damage;   

DOI  :  10.3390/nu12010082

来源: DOAJ

【 摘 要 】

Oxidative stress generated by diabetes plays a key role in the development of diabetic retinopathy (DR), a common diabetic complication. DR remains asymptomatic until it reaches advanced stages, which complicate its treatment. Although it is known that good metabolic control is essential for preventing DR, knowledge of the disease is incomplete and an effective treatment with no side effects is lacking. Pterostilbene (Pter), a natural stilbene with good antioxidant activity, has proved to beneficially affect different pathologies, including diabetes. Therefore, our study aimed to analyse the protective and/or therapeutic capacity of Pter against oxidant damage by characterising early retinal alterations induced by hyperglycaemia, and its possible mechanism of action in a rabbit model of type 1 diabetes mellitus. Pter reduced lipid and protein oxidative damage, and recovered redox status and the main activities of antioxidant enzymes. Moreover, the redox regulation by Pter was associated with activation of the PI3K/AKT/GSK3β/NRF2 pathway. Our results show that Pter is a powerful protective agent that may delay early DR development.

【 授权许可】

Unknown