Similarity of the dog and human gut microbiomes in gene content and response to diet

Microbiome

Coralie Fournier¹  Patrick Descombes¹  Yuanlong Pan²  Qinghong Li²  Gail Czarnecki-Maulden²  Janet R. Jackson²  Sofia K. Forslund³  Thomas Sebastian Benedikt Schmidt³  Matthew Robert Hayward³  Jens Roat Kultima³  Luis Pedro Coelho³  Paul Igor Costea³  Peer Bork³ 

[1] Nestlé Institute of Health Sciences;Nestlé Purina Research;Structural and Computational Biology Unit, European Molecular Biology Laboratory;

关键词: Microbiome;    Diet;    Metagenomics;    Dog microbiome;    Human microbiome;    Mouse microbiome;   

DOI  :  10.1186/s40168-018-0450-3

来源: DOAJ

【 摘 要 】

Abstract Background Gut microbes influence their hosts in many ways, in particular by modulating the impact of diet. These effects have been studied most extensively in humans and mice. In this work, we used whole genome metagenomics to investigate the relationship between the gut metagenomes of dogs, humans, mice, and pigs. Results We present a dog gut microbiome gene catalog containing 1,247,405 genes (based on 129 metagenomes and a total of 1.9 terabasepairs of sequencing data). Based on this catalog and taxonomic abundance profiling, we show that the dog microbiome is closer to the human microbiome than the microbiome of either pigs or mice. To investigate this similarity in terms of response to dietary changes, we report on a randomized intervention with two diets (high-protein/low-carbohydrate vs. lower protein/higher carbohydrate). We show that diet has a large and reproducible effect on the dog microbiome, independent of breed or sex. Moreover, the responses were in agreement with those observed in previous human studies. Conclusions We conclude that findings in dogs may be predictive of human microbiome results. In particular, a novel finding is that overweight or obese dogs experience larger compositional shifts than lean dogs in response to a high-protein diet.

【 授权许可】

Unknown