Serum Metabolic Profile in Patients With Long-Covid (PASC) Syndrome: Clinical Implications

Frontiers in Medicine

Tiziano M. Scarabelli¹  Francesco S. Dioguardi²  Louis Saravolatz³  Evasio Pasini⁴  Carol Chen-Scarabelli⁵  Giovanni Corsetti⁶  Claudia Romano⁶ 

[1] Center for Heart and Vessel Preclinical Studies, St. John Hospital and Medical Center, Wayne State University, Detroit, MI, United States;Department of Internal Medicine, University of Cagliari, Cagliari, Italy;Department of Medicine at St. John Hospital, Wayne State University, Detroit, MI, United States;Division of Cardiac Rehabilitation, Scientific Clinical Institutes Maugeri Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Lumezzane, Italy;Division of Cardiology, Richmond Veterans Affairs Medical Center, Richmond, VA, United States;Division of Human Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy;

关键词: SARS-CoV2;    Long-COVID-syndrome;    PASC;    ferritin;    d-dimer;    COVID-19;   

DOI  :  10.3389/fmed.2021.714426

来源: DOAJ

【 摘 要 】

Background: Many patients who have been suffering by Covid-19 suffer of long-Covid syndrome, with symptoms of fatigue and muscular weakness that characterize post-acute sequelae SARS-CoV-2 infection (PASC). However, there is limited knowledge about the molecular pathophysiology, and about the serum profile of these patients.Methods: We studied the blood serum profile of 75 selected patients, with previous confirmed Covid-19, 2 months after hospital discharge, who reported new-onset fatigue, muscle weakness and/or dyspnea not present prior to the virus infection and independently from concomitant diseases and/or clinical conditions.Results: All patients had very high serum concentrations of ferritin and D-Dimer. 87 and 72% of patients had clinically significant low levels of hemoglobin and albumin, respectively. Seventy three percentage had elevations in erythrocyte sedimentation rate and CRP. Twenty seven percentage had elevations in LDH.Conclusions: The co-existence of patient symptoms along with blood markers of coagulation, protein disarrangement and inflammation suggests ongoing alterations in the metabolism, promoting an inflammatory/hypercatabolic state which maintains a vicious circles implicated in the persistence of PASC. The persistence of altered D-Dimer levels raises the possibility of long-term risks of thromboembolic disease. All these markers levels should be accurately evaluated in the long-term follow-up, with individualized consideration for prophylactic nutritional, anti-inflammatory and/or anticoagulant therapy if indicated.

【 授权许可】

Unknown