Autoimmune pancreatitis type 1 and type 2: A report of two cases

Vojnosanitetski Pregled

Jović Jasna¹  Doder Radoje¹  Brčerević Irina¹  Perišić Nenad²  Petrović Stanko²  Hristović Dejan³  Tasić-Radić Olga⁴  Đorđević Zoran⁵ 

[1] Military Medical Academy, Clinic for Gastroenterology and Hepathology, Belgrade + University of Defence, Faculty of Medicine of the Military Medical Academy, Belgrade;Military Medical Academy, Clinic for Gastroenterology and Hepathology, Belgrade;Military Medical Academy, Clinic for Infectious and Tropical Diseases, Belgrade;Military Medical Academy, Institute of Pathology, Belgrade;Military Medical Academy, Institute of Radiology, Belgrade;

关键词: pancreatitis;    autoimmune diseases;    diagnostic techniques and procedures;    diagnosis, differential;    drug therapy;   

DOI  :  10.2298/VSP151007192B

来源: DOAJ

【 摘 要 】

Introduction. Autoimmune pancreatitis is a disease associated with autoimmune mechanisms, clinically manifested mostly as obstructive icterus with or with no entire or partial enlargement of the pancreas, histological lymphoplas-mocytic infiltration, fibrosis or granulocytic epithelial lesions with a favourable therapeutic response to the application of corticosteroids. Type 1 autoimmune pancreatitis is a systemic disease befalling the group of IgG4-related diseases in contrast to type 2 which is specific for pancreas disease. Case report. We presented two cases. The first one was a 64-year-old male patient with autoimmune pancreatitis complaining of abdominal pain, weight loss, weakness and exhaustion. Clinical examination showed a rare IgG4 autoimmune pancreatitis. The second one was a 37-year-old male patient complaining of abdominal pain with diarrhea. The diagnosis made revealed the presence of type 2 autoimmune pancreatitis. Following the diagnosis, immunosuppressive therapy was administered to both patients leading to the improvement of their general condition. Conclusion. Autoimmune pancreatitis is a rare disease, sometimes not easy to differ from pancreatic tumor or bile duct tumor with poor prognosis. Thus, early recognition of the disease is very important, since adequate treatment significantly increases the course and the outcomes of the disease.

【 授权许可】

Unknown