Association between Beta Adrenergic Receptor Polymorphism and Ischemic Stroke: A Meta-Analysis

Journal of Stroke

Amit Kumar¹  Prachi Kathuria¹  Pradeep Kumar¹  Arun Kumar Yadav¹  Manya Prasad¹  Awadh Kishor Pandit¹ 

[1] Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.;

关键词: β2-adrenergic receptor gene;    β2ar;    ischemic stroke;    cerebral infarction;    polymorphism;    meta-analysis;   

DOI  :  10.5853/jos.2015.17.2.138

来源: DOAJ

【 摘 要 】

Background and PurposeThe purpose of this meta-analysis was to determine the precise association between beta-2 adrenergic receptor (β2AR) polymorphism and Ischemic stroke.MethodsPublished case control studies on association between β2AR and ischemic stroke were searched from electronic databases. Pooled Odds ratio and 95% Confidence interval were calculated by using software RevMan version 5.2.ResultsA total of three studies involving 1,642 cases and 1,673 controls, which were published from 2007 to 2014, were subjected to meta-analysis for allelic association and 518 cases and 510 controls for genotypic association. Pooled analysis of two studies for genotypic association suggested that subjects carrying Gln27Glu polymorphism of β2AR had an increased risk for Ischemic stroke under recessive model (OR 2.09; 95% CI; 1.20 to 3.64) and under dominant model (OR 1.47; 95% CI 1.14 to 1.90). Pooled analysis of three studies for allelic association showed a significantly higher Glu27 allele of β2AR in the patients with ischemic stroke (OR 1.58; 95% CI; 1.38 to 1.81).ConclusionsThe present meta-analysis suggests that Gln27Glu polymorphism of β2AR gene is associated with increased risk for ischemic stroke.

【 授权许可】

Unknown