Genomics of acute myeloid leukemia: the next generation

Frontiers in Oncology

Laura eRiva¹  Pier Giuseppe ePelicci¹  Lucilla eLuzi² 

[1] European Institute of Oncology;IFOM, the FIRC Institute for Molecular Oncology Foundation;

关键词: Acute Myeloid Leukemia;    next generation sequencing;    recurrent mutations;    somatic mutations;   

DOI  :  10.3389/fonc.2012.00040

来源: DOAJ

【 摘 要 】

Acute myeloid leukemia (AML) is, as other types of cancer, a genetic disorder of somatic cells. The detection of somatic molecular abnormalities that may cause and maintain AML is crucial for stratifying patients. The development of mutation-specific therapeutic interventions will hopefully increase cure rates and improve patients’ quality of life. This mini-review illustrates how next generation sequencing (NGS) technologies are changing the study of cancer genomics of adult AML patients.

【 授权许可】

Unknown