Recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment

Cancer Nanotechnology

Yang Gao¹  Qingming Ma¹  Shangcong Han¹  Yong Sun¹  Yan Liang¹  Lijun Liu¹  Jie Cao¹  Tingting Zhang¹  Yang Song² 

[1] Department of Pharmaceutics, School of Pharmacy, Qingdao University;State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University;

关键词: Nanomaterials;    Graphene oxide;    Caner treatment;    Drug and gene delivery;    Phototherapy;    Bioimaging;   

DOI  :  10.1186/s12645-021-00087-7

来源: DOAJ

【 摘 要 】

Abstract Background In the last decade, graphene oxide-based nanomaterials, such as graphene oxide (GO) and reduced graphene oxide (rGO), have attracted more and more attention in the field of biomedicine. Due to the versatile surface functionalization, ultra-high surface area, and excellent biocompatibility of graphene oxide-based nanomaterials, which hold better promise for potential applications than among other nanomaterials in biomedical fields including drug/gene delivery, biomolecules detection, tissue engineering, especially in cancer treatment. Results Here, we review the recent progress of graphene oxide-based multifunctional nanomaterials for cancer treatment. A comprehensive and in-depth depiction of unique property of graphene oxide-based multifunctional nanomaterials is first interpreted, with particular descriptions about the suitability for applying in cancer therapy. Afterward, recently emerging representative applications of graphene oxide-based multifunctional nanomaterials in antitumor therapy, including as an ideal carrier for drugs/genes, phototherapy, and bioimaging, are systematically summarized. Then, the biosafety of the graphene oxide-based multifunctional nanomaterials is reviewed. Conclusions Finally, the conclusions and perspectives on further advancing the graphene oxide-based multifunctional nanomaterials toward potential and versatile development for fundamental researches and nanomedicine are proposed. Graphic abstract

【 授权许可】

Unknown