Lithosepermic Acid Restored the Skin Barrier Functions in the Imiquimod-Induced Psoriasis-like Animal Model

International Journal of Molecular Sciences

Yu-Ping Cheng¹  Jiun-Wen Guo²  Li-Ching Chen³  Chih-Yi Liu⁴ 

[1] Department of Dermatology, Cathay General Hospital, Taipei 10630, Taiwan;Department of Medical Research, Cathay General Hospital, Taipei 10630, Taiwan;Division of Infectious Diseases, Cathay General Hospital, Taipei 10630, Taiwan;Division of Pathology, Sijhih Cathay General Hospital, New Taipei City 22174, Taiwan;

关键词: lithospermic acid;    skin barrier;    inflammatory cytokines;    autophagy;    psoriasis;   

DOI  :  10.3390/ijms23116172

来源: DOAJ

【 摘 要 】

(1) Background: Psoriasis is a T helper 1/T helper 17 cells-involved immune-mediated genetic disease. Lithospermic acid, one of the major phenolic acid compounds of Danshen, has antioxidation and anti-inflammation abilities. Due to the inappropriate molecular weight for topical penetration through the stratum corneum, lithospermic acid was loaded into the well-developed microemulsion delivery system for IMQ-induced psoriasis-like dermatitis treatment. (2) Methods: BALB/c mice were administered with topical imiquimod to induce psoriasis-like dermatitis. Skin barrier function, disease severity, histology assessment, autophagy-related protein expression, and skin and spleen cytokine expression were evaluated. (3) Results: The morphology, histopathology, and skin barrier function results showed that 0.1% lithospermic acid treatment ameliorated the IMQ-induced psoriasis-like dermatitis and restored the skin barrier function. The cytokines array results confirmed that 0.1% lithospermic acid treatment inhibited the cutaneous T helper-17/Interleukin-23 axis related cytokines cascades. (4) Conclusions: The results implied that lithospermic acid might represent a possible new therapeutic agent for psoriasis treatment.

【 授权许可】

Unknown