Current Concepts and Future Trends in Increasing the Benefits of Cochlear Implantation: A Narrative Review

Medicina

Marcel Cosgarea¹  Cristina Maria Blebea¹  Mirela Cristina Stamate¹  Violeta Necula¹  Maximilian George Dindelegan¹  Laszlo Peter Ujvary¹  Alma Aurelia Maniu¹  Maria Perde-Schrepler² 

[1] Department of Otorhinolaryngology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 400347 Cluj Napoca, Romania;Institute of Oncology “Prof.Dr. Ion Chiricuta”, 400015 Cluj Napoca, Romania;

关键词: cochlear implant;    hearing loss;    deafness;    review;    nanomaterials;    dexamethasone;   

DOI  :  10.3390/medicina58060747

来源: DOAJ

【 摘 要 】

Hearing loss is the most common neurosensory disorder, and with the constant increase in etiological factors, combined with early detection protocols, numbers will continue to rise. Cochlear implantation has become the gold standard for patients with severe hearing loss, and interest has shifted from implantation principles to the preservation of residual hearing following the procedure itself. As the audiological criteria for cochlear implant eligibility have expanded to include patients with good residual hearing, more attention is focused on complementary development of otoprotective agents, electrode design, and surgical approaches. The focus of this review is current aspects of preserving residual hearing through a summary of recent trends regarding surgical and pharmacological fundamentals. Subsequently, the assessment of new pharmacological options, novel bioactive molecules (neurotrophins, growth factors, etc.), nanoparticles, stem cells, and gene therapy are discussed.

【 授权许可】

Unknown