Effect of Systemic Administration of Curcumin on Ischemia-Reperfusion Injury in Ovaries: An Animal Model Study

Iranian Journal of Veterinary Surgery

Ali Javadi-Afshar¹  Alireza Najafpour¹ 

[1] Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.;

关键词: ischemia-reperfusion;    curcumin;    Intraperitoneal;    Ovary;   

DOI  :  10.22034/ivsa.2019.154065.1164

来源: DOAJ

【 摘 要 】

Objective-Ovarian torsion must be diagnosed and treated as much early as possible. The aim of the present study was to investigate effects of interaperitoneal administration of curcumin on ischemia-reperfusion injury in ovaries.
Design- Experimental Study
Animals- Twent-four healthy female Wistar rats
Procedures- Twent-four healthy female Wistar rats weighing approximately 260g were randomized into four experimental groups (n = 6): Group Sham: The rats underwent only laparotomy. Group I: A 3- hour ischemia only. Group I/R: A 3-hour ischemia and a 3-hour reperfusion. Group I/R/C: A 3-hour ischemia, a 3-hour reperfusion and 1 mg/kg interaperitoneal administration of curcumin 2.5 hours after induction of ischemia.
Results-Curcumin treated animals showed significantly ameliorated development of ischemia and reperfusion tissue injury compared to those of other groups (P<0.05). The significant higher values of SOD, GPO and GST were observed in I/R/C animals compared to those of other groups (P<0.05). The damage indicators (MDA) was significantly lower in I/R/C animal compared to those of other groups (P<0.05).
Conclusion and Clinical Relevance- Interaperitoneal administration of curcumin could be helpful in minimizing ischemia-reperfusion injury in ovarian tissue exposed to ischemia.

【 授权许可】

Unknown