Role of Emollients in Prevention of the Comorbid Allergic Diseases Development in Children with Atopic Dermatitis

Pediatričeskaâ Farmakologiâ

Dmitri V. Fedorov¹  Eduard T. Ambarchyan²  Roman A. Ivanov³  Alexander I. Materikin⁴  Nikolay N. Murashkin⁴  Leonid A. Opryatin⁴  Alena A. Savelova⁴  Roman V. Epishev⁴ 

[1] Central State Medical Academy of Department of Presidential Affairs;Research Institute of Pediatrics and Children’s Health in «Central Clinical Hospital of the Russian Academy of Sciences»;Sechenov First Moscow State Medical University;National Medical Research Center of Children’s Health;

关键词: atopic dermatitis;    epidermal barrier;    atopic march;    emollients;   

DOI  :  10.15690/pf.v17i4.2160

来源: DOAJ

【 摘 要 】

Atopic dermatitis (AD) is one of the common multifactorial inflammatory diseases manifesting predominantly in childhood. There is significant number of cases of self-regression of the disease with aging. On the other hand, there is also another scenario ending with AD persistent course and/or development of comorbid allergic pathologies that can significantly worsen patient’s quality of life and finally lead to social maladjustment. The pathogenesis of such way includes epidermal barrier disturbance, transcutaneous sensibilisation and aberrant allergic (Th2) immune systemic response development. Main role in preventing of this pathological pathway is lying on the new class of moisturizers containing active components "emollients plus". They are considered as foundation for the therapy and prevention of the development of AD and other allergic diseases. This literature review provides relevant data on AD pathogenesis and development of comorbid allergic pathologies. This paper also covers data on the effect of emollients in restoration of the epidermal barrier and their use as preventive measures.

【 授权许可】

Unknown