The Role of Decorin and Biglycan Signaling in Tumorigenesis

Frontiers in Oncology

Malgorzata Wygrecka¹  Jonel Trebicka²  Renato V. Iozzo³  Lisa Sophie Huber⁴  Valentina Diehl⁴  Liliana Schaefer⁴ 

[1] Center for Infection and Genomics of the Lung, Member of the German Center for Lung Research, University of Giessen and Marburg Lung Center, Giessen, Germany;Department of Internal Medicine I, Goethe University, Frankfurt, Germany;Department of Pathology, Anatomy and Cell Biology and the Translational Cellular Oncology Program, Sidney Kimmel Cancer Center, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, United States;Institute of Pharmacology and Toxicology, Goethe University, Frankfurt, Germany;

关键词: extracellular matrix;    proteoglycan;    autophagy;    inflammation;    angiogenesis;    cancer;   

DOI  :  10.3389/fonc.2021.801801

来源: DOAJ

【 摘 要 】

The complex and adaptive nature of malignant neoplasm constitute a major challenge for the development of effective anti-oncogenic therapies. Emerging evidence has uncovered the pivotal functions exerted by the small leucine-rich proteoglycans, decorin and biglycan, in affecting tumor growth and progression. In their soluble forms, decorin and biglycan act as powerful signaling molecules. By receptor-mediated signal transduction, both proteoglycans modulate key processes vital for tumor initiation and progression, such as autophagy, inflammation, cell-cycle, apoptosis, and angiogenesis. Despite of their structural homology, these two proteoglycans interact with distinct cell surface receptors and thus modulate distinct signaling pathways that ultimately affect cancer development. In this review, we summarize growing evidence for the complex roles of decorin and biglycan signaling in tumor biology and address potential novel therapeutic implications.

【 授权许可】

Unknown