期刊论文详细信息
Frontiers in Aging Neuroscience
Age-associated changes in the hippocampal-ventral striatum-ventral tegmental loop that impact learning, prediction and context discrimination
Marsha R Penner1  Sheri JY Mizumori1 
[1] University of Washington;
关键词: Decision Making;    Hippocampus;    Ventral Tegmental Area;    ventral striatum;    adaptive navigation;    context discrimination;   
DOI  :  10.3389/fnagi.2012.00022
来源: DOAJ
【 摘 要 】

Studies of the neural mechanisms of navigation and context discrimination have generated a powerful heuristic for understanding how neural codes, circuits and computations contribute to accurate behavior as animals traverse and learn about spatially-extended environments. It is assumed that memories are updated as a result of spatial experience. The mechanism, however, for such a process is not clear. Here we suggest that one revealing approach to study this issue is to integrate our knowledge about limbic system mediated navigation and context discrimination with knowledge about how midbrain neural circuitry mediates decision making. This perspective should lead to new and specific neural theories about how choices that we make during navigation determine what information is ultimately learned and remembered. This same circuitry may be involved when past experiences come to bias future spatial perceptions and response selection. With old age come not only important changes in limbic system operations, but also significant decline in the function of midbrain regions that underlie accurate and efficient decisions. Thus suboptimal accuracy of spatial context-based decision making may be at least in part responsible for the common observation of spatial memory decline in old age.

【 授权许可】

Unknown   

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