Urinary trace metals, maternal circulating angiogenic biomarkers, and preeclampsia: a single-contaminant and mixture-based approach

Environmental Health

John D. Meeker¹  David E. Cantonwine²  Thomas F. McElrath²  Paige A. Bommarito³  Rebecca C. Fry³  Stephani S. Kim⁴  Kelly K. Ferguson⁴ 

[1] Department of Environmental Health Sciences, University of Michigan School of Public Health;Division of Maternal-Fetal Medicine, Brigham and Women’s Hospital, Harvard Medical School;Environmental Science and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill;Epidemiology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences;

关键词: Prenatal exposure;    Metals;    Metals mixtures;    Angiogenic biomarkers;    Preeclampsia;   

DOI  :  10.1186/s12940-019-0503-5

来源: DOAJ

【 摘 要 】

Abstract Background Exposures to toxic metals and deficiencies in essential metals disrupt placentation and may contribute to preeclampsia. However, effects of exposure to combinations of metals remain unknown. Objective We investigated the relationship between urinary trace metals, circulating angiogenic biomarkers, and preeclampsia using the LIFECODES birth cohort. Methods Urine samples collected during pregnancy were analyzed for 17 trace metals and plasma samples were analyzed for soluble fms-like tyrosine-1 (sFlt-1) and placental growth factor (PlGF). Cox proportional hazard models were used to estimate the hazard ratios (HR) of preeclampsia associated with urinary trace metals. Linear regression models were used to estimate the relationship between urinary trace metals and angiogenic biomarkers. Principal components analysis (PCA) was used to identify groups of metals and interactions between principal components (PCs) loaded by toxic and essential metals were examined. Results In single-contaminant models, several toxic and essential metals were associated with lower PlGF and higher sFlt-1/PlGF ratio. Detection of urinary chromium was associated with preeclampsia: HR (95% Confidence Interval [CI]) = 3.48 (1.02, 11.8) and an IQR-increase in urinary selenium was associated with reduced risk of preeclampsia (HR: 0.28, 95% CI: 0.08, 0.94). Using PCA, 3 PCs were identified, characterized by essential metals (PC1), toxic metals (PC2), and seafood-associated metals (PC3). PC1 and PC2 were associated with lower PlGF levels, but not preeclampsia risk in the overall cohort. Conclusions Trace urinary metals may be associated with adverse profiles of angiogenic biomarkers and preeclampsia.

【 授权许可】

Unknown