Global diversity of policy, coverage, and demand of COVID-19 vaccines: a descriptive study

BMC Medicine

Andrew S. Azman¹  Qianhui Wu²  Cheng Peng²  Xinghui Chen²  Nuolan Liu²  Juan Yang²  Wen Zheng²  Minghan Wang²  Xiaoyu Zhou²  Zeyao Zhao²  Feiran Hao²  Jiayi Dong²  Tingyu Zhuang²  Ruijia Sun²  Sihong Zhao²  Xuemei Yan²  Zhiyuan Chen²  Hongjie Yu²  Yuyang Tian²  Guangjie Zhong² 

[1] Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health;School of Public Health, Fudan University, Key Laboratory of Public Health Safety, Ministry of Education;

关键词: COVID-19 vaccines;    Vaccination policy;    Vaccine coverage;    Vaccine demand;    Global diversity;   

DOI  :  10.1186/s12916-022-02333-0

来源: DOAJ

【 摘 要 】

Abstract Background Hundreds of millions of doses of coronavirus disease 2019 (COVID-19) vaccines have been administered globally, but progress on vaccination varies considerably between countries. We aimed to provide an overall picture of COVID-19 vaccination campaigns, including policy, coverage, and demand of COVID-19 vaccines. Methods We conducted a descriptive study of vaccination policy and doses administered data obtained from multiple public sources as of 8 February 2022. We used these data to develop coverage indicators and explore associations of vaccine coverage with socioeconomic and healthcare-related factors. We estimated vaccine demand as numbers of doses required to complete vaccination of countries’ target populations according to their national immunization program policies. Results Messenger RNA and adenovirus vectored vaccines were the most commonly used COVID-19 vaccines in high-income countries, while adenovirus vectored vaccines were the most widely used vaccines worldwide (180 countries). One hundred ninety-two countries have authorized vaccines for the general public, with 40.1% (77/192) targeting individuals over 12 years and 32.3% (62/192) targeting those ≥ 5 years. Forty-eight and 151 countries have started additional-dose and booster-dose vaccination programs, respectively. Globally, there have been 162.1 doses administered per 100 individuals in target populations, with marked inter-region and inter-country heterogeneity. Completed vaccination series coverage ranged from 0.1% to more than 95.0% of country target populations, and numbers of doses administered per 100 individuals in target populations ranged from 0.2 to 308.6. Doses administered per 100 individuals in whole populations correlated with healthcare access and quality index (R 2 = 0.59), socio-demographic index (R 2 = 0.52), and gross domestic product per capita (R 2 = 0.61). At least 6.4 billion doses will be required to complete interim vaccination programs—3.3 billion for primary immunization and 3.1 billion for additional/booster programs. Globally, 0.53 and 0.74 doses per individual in target populations are needed for primary immunization and additional/booster dose programs, respectively. Conclusions There is wide country-level disparity and inequity in COVID-19 vaccines rollout, suggesting large gaps in immunity, especially in low-income countries.

【 授权许可】

Unknown