Spontaneous Intracerebral Hemorrhage Due to Delta Storage Pool Disease in a Patient on a Serotonin-Norepinephrine Reuptake Inhibitor

Frontiers in Neurology

Annette Leibetseder¹  Hans-Peter Haring¹  Tim J. von Oertzen¹  Judith Wagner¹  Markus Hutterer¹  Josef Tomasits²  Johannes Trenkler³ 

[1] Department of Neurology 1, Kepler University Hospital, Medical Faculty of the Johannes Kepler University Linz, Linz, Austria;Institute for Clinical Pathology, Kepler University Hospital, Medical Faculty of the Johannes Kepler University Linz, Linz, Austria;Institute of Neuroradiology, Kepler University Hospital, Medical Faculty of the Johannes Kepler University Linz, Linz, Austria;

关键词: intracerebral hemorrhage;    stroke;    SSRI;    SNRI;    thrombocytopathy;    delta storage pool disease;   

DOI  :  10.3389/fneur.2019.01257

来源: DOAJ

【 摘 要 】

We report a case of spontaneous intracerebral hemorrhage (sICH) due to delta storage pool disease in a 60-year-old female on a serotonin-norepinephrine reuptake inhibitor (SNRI). Increased susceptibility to SNRI-effects on hemostasis was due to a genetic disposition mediated by a polymorphism of the SLC6A4 gene coding for the human serotonin transporter (SERT). Pathophysiological and clinical implications of these findings are discussed.

【 授权许可】

Unknown