Prognostic Value of Radiomic Features of 18F-FDG PET/CT in Patients With B-Cell Lymphoma Treated With CD19/CD22 Dual-Targeted Chimeric Antigen Receptor T Cells

Frontiers in Oncology

Xiaoyi Zhang¹  Yeye Zhou²  Jihui Li²  Shibiao Sang²  Tongtong Jia²  Na Dai²  Bin Zhang²  Shengming Deng⁴ 

[1] Department of Nuclear Medicine, Changshu No. 2 People’s Hospital, Changshu, China;Department of Nuclear Medicine, the First Affiliated Hospital of Soochow University, Suzhou, China;Nuclear Medicine Laboratory of Mianyang Central Hospital, Mianyang, China;State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou, China;

关键词: CAR-T;    B-cell lymphoma;    radiomics;    PET/CT;    prognosis;   

DOI  :  10.3389/fonc.2022.834288

来源: DOAJ

【 摘 要 】

ObjectiveIn the present study, we aimed to evaluate the prognostic value of PET/CT-derived radiomic features for patients with B-cell lymphoma (BCL), who were treated with CD19/CD22 dual-targeted chimeric antigen receptor (CAR) T cells. Moreover, we explored the relationship between baseline radiomic features and the occurrence probability of cytokine release syndrome (CRS).MethodsA total of 24 BCL patients who received 18F-FDG PET/CT before CAR T-cell infusion were enrolled in the present study. Radiomic features from PET and CT images were extracted using LIFEx software, and the least absolute shrinkage and selection operator (LASSO) regression was used to select the most useful predictive features of progression-free survival (PFS) and overall survival (OS). Receiver operating characteristic curves, Cox proportional hazards model, and Kaplan-Meier curves were conducted to assess the potential prognostic value.ResultsContrast extracted from neighbourhood grey-level different matrix (NGLDM) was an independent predictor of PFS (HR = 15.16, p = 0.023). MYC and BCL2 double-expressor (DE) was of prognostic significance for PFS (HR = 7.02, p = 0.047) and OS (HR = 10.37, p = 0.041). The combination of NGLDM_ContrastPET and DE yielded three risk groups with zero (n = 7), one (n = 11), or two (n = 6) factors (p < 0.0001 and p = 0.0004, for PFS and OS), respectively. The PFS was 85.7%, 63.6%, and 0%, respectively, and the OS was 100%, 90.9%, and 16.7%, respectively. Moreover, there was no significant association between PET/CT variables and CRS.ConclusionsIn conclusion, radiomic features extracted from baseline 18F-FDG PET/CT images in combination with genomic factors could predict the survival outcomes of BCL patients receiving CAR T-cell therapy.

【 授权许可】

Unknown