Regulation of NRG-1-ErbB4 signaling and neuroprotection by exogenous neuregulin-1 in a mouse model of epilepsy

Neurobiology of Disease

Devin K. Binder¹  Terese A. Garcia²  Allison R. Peterson²  Byron D. Ford² 

[1] Corresponding author at: Division of Biomedical Sciences, University of California, Riverside, 1247 Webber Hall, Riverside, CA 92521, USA.;Division of Biomedical Sciences, School of Medicine, Center for Glial-Neuronal Interactions, University of California, Riverside, CA, USA;

关键词: Neuregulin-1;    Epilepsy;    ErbB4;    Neuroprotection;    EAAC1;    Glutamate synthetase;   

DOI  :  

来源: DOAJ

【 摘 要 】

Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy. Dysregulation of glutamate transporters has been a common finding across animal models of epilepsy and in patients with TLE. In this study, we investigate NRG-1/ErbB4 signaling in epileptogenesis and the neuroprotective effects of NRG-1 treatment in a mouse model of temporal lobe epilepsy. Using immunohistochemistry, we report the first evidence for NRG-1/ErbB4-dependent selective upregulation of glutamate transporter EAAC1 and bihemispheric neuroprotection by exogeneous NRG-1 in the intrahippocampal kainic acid (IHKA) model of TLE. Our findings provide evidence that dysregulation of glutamate transporter EAAC1 contributes to the development of epilepsy and can be therapeutically targeted to reduce neuronal death following IHKA-induced status epilepticus (SE).

【 授权许可】

Unknown