期刊论文详细信息
Diagnostics
The Use of 18F-FET-PET-MRI in Neuro-Oncology: The Best of Both Worlds—A Narrative Review
Martijn P. G. Broen1  Monique Anten1  Cristina Mitea2  Tineke van de Weijer2  Rik P. M. Moonen2  Toine M. Lodewick2  Felix M. Mottaghy2  Alida A. Postma2  Jochem A. J. van der Pol2  Joachim E. Wildberger2  Arnaud Jacquerie2  Inge Compter3  Ann Hoeben3  Koos Hovinga3 
[1] Department of Neurology, Maastricht University Medical Center+, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;Department of Radiology and Nuclear Medicine, Maastricht University Medical Center+, P.O. Box 5800, 6202 AZ Maastricht, The Netherlands;School for Oncology and Reproduction (GROW), P.O. Box 616, 6200 MD Maastricht, The Netherlands;
关键词: glioma;    FET-PET;    MRI;    PET-MRI;   
DOI  :  10.3390/diagnostics12051202
来源: DOAJ
【 摘 要 】

Gliomas are the most frequent primary tumors of the brain. They can be divided into grade II-IV astrocytomas and grade II-III oligodendrogliomas, based on their histomolecular profile. The prognosis and treatment is highly dependent on grade and well-identified prognostic and/or predictive molecular markers. Multi-parametric MRI, including diffusion weighted imaging, perfusion, and MR spectroscopy, showed increasing value in the non-invasive characterization of specific molecular subsets of gliomas. Radiolabeled amino-acid analogues, such as 18F-FET, have also been proven valuable in glioma imaging. These tracers not only contribute in the diagnostic process by detecting areas of dedifferentiation in diffuse gliomas, but this technique is also valuable in the follow-up of gliomas, as it can differentiate pseudo-progression from real tumor progression. Since multi-parametric MRI and 18F-FET PET are complementary imaging techniques, there may be a synergistic role for PET-MRI imaging in the neuro-oncological imaging of primary brain tumors. This could be of value for both primary staging, as well as during treatment and follow-up.

【 授权许可】

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