Dysregulation of miRNA in Leukemia: Exploiting miRNA Expression Profiles as Biomarkers

International Journal of Molecular Sciences

Luisa Anelli¹  Francesco Albano¹  Pellegrino Musto¹  Antonella Zagaria¹  Giorgina Specchia² 

[1] Department of Emergency and Organ Transplantation (D.E.T.O.), Hematology and Stem Cell Transplantation Unit, University of Bari “Aldo Moro”, 70100 Bari, Italy;School of Medicine, University of Bari ‘Aldo Moro’, 70100 Bari, Italy;

关键词: circulating miRNAs;    epigenetic miRNAs;    biomarkers;    dysregulated expression;   

DOI  :  10.3390/ijms22137156

来源: DOAJ

【 摘 要 】

Micro RNAs (miRNAs) are a class of small non-coding RNAs that have a crucial role in cellular processes such as differentiation, proliferation, migration, and apoptosis. miRNAs may act as oncogenes or tumor suppressors; therefore, they prevent or promote tumorigenesis, and abnormal expression has been reported in many malignancies. The role of miRNA in leukemia pathogenesis is still emerging, but several studies have suggested using miRNA expression profiles as biomarkers for diagnosis, prognosis, and response to therapy in leukemia. In this review, the role of miRNAs most frequently involved in leukemia pathogenesis is discussed, focusing on the class of circulating miRNAs, consisting of cell-free RNA molecules detected in several body fluids. Circulating miRNAs could represent new potential non-invasive diagnostic and prognostic biomarkers of leukemia that are easy to isolate and characterize. The dysregulation of some miRNAs involved in both myeloid and lymphoid leukemia, such as miR-155, miR-29, let-7, and miR-15a/miR-16-1 clusters is discussed, showing their possible employment as therapeutic targets.

【 授权许可】

Unknown