Potential New Therapies for Pediatric Diffuse Intrinsic Pontine Glioma

Frontiers in Pharmacology

Qi Cao¹  Yang Yi²  Wei Zhao²  Shen Chen²  Qing Liu³  Wenyong Long³ 

[1] Center for Inflammation and Epigenetics, Houston Methodist Research Institute, HoustonTX, United States;Department of Histology and Embryology, Zhongshan School of Medicine, Sun Yat-sen UniversityGuangzhou, China;Department of Neurosurgery, Xiangya Hospital, Central South UniversityChangsha, China;Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen UniversityGuangzhou, China;

关键词: DIPG;    H3K27M;    epigenetic therapy;    immunotherapy;    stem cells;    nanoparticles;   

DOI  :  10.3389/fphar.2017.00495

来源: DOAJ

【 摘 要 】

Diffuse intrinsic pontine glioma (DIPG) is an extensively invasive malignancy with infiltration into other regions of the brainstem. Although large numbers of specific targeted therapies have been tested, no significant progress has been made in treating these high-grade gliomas. Therefore, the identification of new therapeutic approaches is of great importance for the development of more effective treatments. This article reviews the conventional therapies and new potential therapeutic approaches for DIPG, including epigenetic therapy, immunotherapy, and the combination of stem cells with nanoparticle delivery systems.

【 授权许可】

Unknown