Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging

International Journal of Molecular Sciences

Esther Barreiro¹  Sabah N. A. Hussain²  Gilles Gouspillou²  Jean-Philippe Leduc-Gaudet² 

[1] Pulmonology Department-Muscle Wasting & Cachexia in Chronic Respiratory Diseases & Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Biomedical Research Park (PRBB), C/Dr. Aiguader, 88, 08003 Barcelona, Spain;Research Institute of the McGill University Health Centre, Department of Critical Care, Montréal, QC H4A 3J1, Canada;

关键词: skeletal muscle;    mitochondrial dynamics;    mitophagy;    autophagy;    aging;    sarcopenia;   

DOI  :  10.3390/ijms22158179

来源: DOAJ

【 摘 要 】

The maintenance of mitochondrial integrity is critical for muscle health. Mitochondria, indeed, play vital roles in a wide range of cellular processes, including energy supply, Ca²⁺ homeostasis, retrograde signaling, cell death, and many others. All mitochondria-containing cells, including skeletal muscle cells, dispose of several pathways to maintain mitochondrial health, including mitochondrial biogenesis, mitochondrial-derived vesicles, mitochondrial dynamics (fusion and fission process shaping mitochondrial morphology), and mitophagy—the process in charge of the removal of mitochondria though autophagy. The loss of skeletal muscle mass (atrophy) is a major health problem worldwide, especially in older people. Currently, there is no treatment to counteract the progressive decline in skeletal muscle mass and strength that occurs with aging, a process termed sarcopenia. There is increasing data, including our own, suggesting that accumulation of dysfunctional mitochondria contributes to the development of sarcopenia. Impairments in mitochondrial dynamics and mitophagy were recently proposed to contribute to sarcopenia. This review summarizes the current state of knowledge on the role played by mitochondrial dynamics and mitophagy in skeletal muscle health and in the development of sarcopenia. We also highlight recent studies showing that enhancing mitophagy in skeletal muscle is a promising therapeutic target to prevent or even treat skeletal muscle dysfunction in the elderly.

【 授权许可】

Unknown