A Prospective Study on Serum Methylmalonic Acid and Homocysteine in Pregnant Women

Nutrients

Yaeji Lim¹  Sunkyu Choi²  Rihwa Choi³  Soo-Youn Lee³  Soo-young Oh⁴  Hye Jeong Kim⁵  Sun Wook Kim⁵  Yoon Young Cho⁵  Jae Hoon Chung⁵ 

[1] Biostatistics Team, Samsung Biomedical Research Institute, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea;Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea;Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea;Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea;Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea;

关键词: methylmalonic acid;    homocysteine;    vitamin B12;    pregnancy;   

DOI  :  10.3390/nu8120797

来源: DOAJ

【 摘 要 】

This study aimed to investigate serum methylmalonic acid (MMA) and homocysteine levels and to assess their effects on pregnancy and neonatal outcomes. Serum MMA and homocysteine levels in 278 pregnant Korean women, determined by liquid chromatography–tandem mass spectrometry in each trimester, were compared with those of previous studies in other ethnic groups. We investigated the association between MMA and homocysteine status with pregnancy and neonatal events: gestational diabetes, preeclampsia, gestational age at delivery, preterm birth, small for gestational age, neonatal birth weight, and congenital abnormalities. The median (range) MMA level was 0.142 (0.063–0.446) µmol/L and homocysteine level was 10.6 (4.4–38.0) µmol/L in pregnant women. MMA levels were significantly higher in the third trimester than during other trimesters (p < 0.05), while homocysteine levels were not. No significant association was observed between MMA or homocysteine levels and any of the maternal or neonatal outcomes examined. Future studies are needed to assess the associations among maternal serum concentrations of MMA and homocysteine, and maternal and neonatal outcomes.

【 授权许可】

Unknown