Thermodynamic Interaction between PAMAM G4-NH2, G4-OH,G3.5-COONaDendrimers and Gemcitabine in Water Sotutions

International Journal of Secondary Metabolite

Özge Kılınçarslan¹  Bartlomiej Palecz²  Henryk Piekarski²  Adam Buczkowski² 

[1] Pamukkale University;University of Lodz;

关键词: PAMAM dendrimers G-4,gemcitabine hydrochloride, isothermal titration calorimetry;   

DOI  :  

来源: DOAJ

【 摘 要 】

The thermodynamics of complex formation of polyamideamine dendrimers: cationic PAMAM G4-NH₂, neutral PAMAM G4-OH and anionic PAMAM G3.5-COONa with gemcitabine hydrochloride, an antitumor drug, in water at a temperature of 25⁰C was studied. The investigations were carried out with the use of ITC measurements allowing one to determine the number of the drug molecules bonded by the dendrimer macromolecule, the equilibrium constants of the complex formed and the values of enthalpy and entropy of their formation. The measurements results obtained show different numbers of the drug molecules bonded by dendrimer macromolecules depending on the properties of their terminal groups.

【 授权许可】

Unknown