期刊论文详细信息
Molecules | |
Cu (II)-Catalyzed Asymmetric Henry Reaction with a NovelC1-Symmetric Aminopinane-Derived Ligand | |
Trond Vidar Hansen1  Yngve Stenstrøm1  Liudmila Filippova1  | |
[1] Department of Chemistry, Biology and Food Science, Norwegian University of Life Sciences,P.O. Box 5003, N-1432 Ås, Norway; | |
关键词: asymmetric catalysis; Henry reaction; nitrooaldol; chiral ligand; copper; | |
DOI : 10.3390/molecules20046224 | |
来源: DOAJ |
【 摘 要 】
A novel C1-symmetric dinitrogen ligand was synthesized in high yield from commercially available (1R,2R,3R,5S)-(−)-isopinocampheylamine and 1-methyl-2-imidazolecarboxaldehyde. In combination with Cu(OAc)2H2O, this new ligand promote the reaction between nitromethane and aliphatic aldehydes with high yields (up to 97%) and moderate enantioselectivities (up to 67% ee). The reactions with benzaldehyde required prolonged reaction time that resulted in diminished yields, but accompanied with ee-values in the 55%–76% range.
【 授权许可】
Unknown