The Dominant Role of Forkhead Box Proteins in Cancer

International Journal of Molecular Sciences

NguyenHoang Anh¹  Duc-Hiep Bach¹  NguyenPhuoc Long¹  Thi-Thu-Trang Luu¹  SungWon Kwon¹  SangKook Lee¹ 

[1] College of Pharmacy, Seoul National University, Seoul 08826, Korea;

关键词: FOX proteins;    FOXA;    FOXC;    FOXP;    FOXO-FOXM1;    hallmarks of cancer;    drug resistance;    genomic alterations;    miRNAs;   

DOI  :  10.3390/ijms19103279

来源: DOAJ

【 摘 要 】

Forkhead box (FOX) proteins are multifaceted transcription factors that are significantly implicated in cancer, with various critical roles in biological processes. Herein, we provide an overview of several key members of the FOXA, FOXC, FOXM1, FOXO and FOXP subfamilies. Important pathophysiological processes of FOX transcription factors at multiple levels in a context-dependent manner are discussed. We also specifically summarize some major aspects of FOX transcription factors in association with cancer research such as drug resistance, tumor growth, genomic alterations or drivers of initiation. Finally, we suggest that targeting FOX proteins may be a potential therapeutic strategy to combat cancer.

【 授权许可】

Unknown