Reflection of Dietary Iodine in the 24 h Urinary Iodine Concentration, Serum Iodine and Thyroglobulin as Biomarkers of Iodine Status: A Pilot Study

Nutrients

Brenda M. Alexander¹  Katelyn Hlucny²  D. Enette Larson-Meyer³  Ken Gerow⁴ 

[1] Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA;Department of Family and Consumer Sciences, University of Wyoming, Laramie, WY 82071, USA;Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, VA 24061, USA;Department of Mathematics and Statistics, University of Wyoming, Laramie, WY 82071, USA;

关键词: iodine status;    biomarkers;    validation;    nutritional exposure;    dietary biomarkers;    iodine intake;   

DOI  :  10.3390/nu13082520

来源: DOAJ

【 摘 要 】

Background: The iodine status of the US population is considered adequate, but subpopulations remain at risk for iodine deficiency and a biomarker of individual iodine status has yet to be determined. The purpose of this study was to determine whether a 3 day titration diet, providing known quantities of iodized salt, is reflected in 24 h urinary iodine concentration (UIC), serum iodine, and thyroglobulin (Tg). Methods: A total of 10 participants (31.3 ± 4.0 years, 76.1 ± 6.3 kg) completed three, 3 day iodine titration diets (minimal iodine, US RDA, (United States Recommended Daily Allowance), and 3× RDA). The 24 h UIC, serum iodine, and Tg were measured following each diet. The 24 h UIC and an iodine-specific food frequency questionnaire (FFQ) were completed at baseline. Results: UIC increased an average of 19.3 μg/L for every gram of iodized salt consumed and was different from minimal to RDA (p = 0.001) and RDA to 3× RDA diets (p = 0.04). Serum iodine was different from RDA to 3× RDA (p = 0.006) whereas Tg was not responsive to diet. Baseline UIC was associated with iodine intake from milk (r = 0.688, p = 0.028) and fish/seafood (r = 0.646, p = 0.043). Conclusion: These results suggest that 24 h UIC and serum iodine may be reflective of individual iodine status and may serve as biomarkers of iodine status.

【 授权许可】

Unknown