Nanotechnology assisted photo- and sonodynamic therapy for overcoming drug resistance

Cancer Biology & Medicine

Zhimin Chen¹  Rui Li¹  Zhifei Dai²  Yingjie Yu³ 

[1] College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China;Department of Biomedical Engineering, College of Engineering, Peking University, Beijing 100871, China;Institute of Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People’s Hospital, Shenzhen 518039, China;

关键词: drug resistance;    photodynamic therapy;    sonodynamic therapy;    chemotherapy;    nanotechnology;   

DOI  :  10.20892/j.issn.2095-3941.2020.0328

来源: DOAJ

【 摘 要 】

Drug resistance is considered the most important reason for the clinical failure of cancer chemotherapy. Circumventing drug resistance and improving the efficacy of anticancer agents remains a major challenge. Over the past several decades, photodynamic therapy (PDT) and sonodynamic therapy (SDT) have attracted substantial attention for their efficacy in cancer treatment, and have been combined with chemotherapy to overcome drug resistance. However, simultaneously delivering sensitizers and chemotherapy drugs to same tumor cell remains challenging, thus greatly limiting this combinational therapy. The rapid development of nanotechnology provides a new approach to solve this problem. Nano-based drug delivery systems can not only improve the targeted delivery of agents but also co-deliver multiple drug components in single nanoparticles to achieve optimal synergistic effects. In this review, we briefly summarize the mechanisms of drug resistance, discuss the advantages and disadvantages of PDT and SDT in reversing drug resistance, and describe state-of-the-art research using nano-mediated PDT and SDT to solve these refractory problems. This review also highlights the clinical translational potential for this combinational therapy.

【 授权许可】

Unknown