Preclinical Assessment Addressing Intravenous Administration of a [68Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution

Molecules

Lonji Kalombo¹  Vusani Mandiwana¹  Thomas Ebenhan²  Rose Hayeshi²  JanRijn Zeevaart² 

[1]Centre for Nanostructures and Advanced Materials CeNAM, Chemical Cluster, Advanced Functional Materials, Council for Scientific and Industrial Research, Pretoria 0001, South Africa

[2]Department of Science and Technology, Preclinical Drug Development Platform, North West University, Potchefstroom 2520, South Africa

关键词: biodistribution;    ⁶⁸Ga;    [⁶⁸Ga]Ga-PSMA-617-ME;    in vivo;    microemulsion;    microPET/CT;   

DOI  :  10.3390/molecules26092650

来源: DOAJ

【 摘 要 】

It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [⁶⁸Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [⁶⁸Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.

【 授权许可】

Unknown