Clinical and Immunological Biomarkers for Systemic Lupus Erythematosus

Biomolecules

Yasuo Nagafuchi¹  Keishi Fujio¹  Haitao Yu² 

[1] Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-8655, Japan;Department of Laboratory Medicine, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou 730000, China;

关键词: systemic lupus erythematosus;    biomarkers;    diagnosis;    monitoring;    omics;   

DOI  :  10.3390/biom11070928

来源: DOAJ

【 摘 要 】

Systemic lupus erythematosus (SLE) is characterized by immune system dysfunction and is clinically heterogeneous, exhibiting renal, dermatological, neuropsychiatric, and cardiovascular symptoms. Clinical and physiological assessment is usually inadequate for diagnosing and assessing pathophysiological processes in SLE. Clinical and immunological biomarkers could play a critical role in improving diagnosis, assessment, and ultimately, control of SLE. This article reviews clinical and immunological biomarkers that could diagnose and monitor disease activity in SLE, with and without organ-specific injury. In addition, novel SLE biomarkers that have been discovered through “omics” research are also reviewed.

【 授权许可】

Unknown