The Neutrophil to Lymphocyte Ratio Is Associated With the Risk of Subsequent Dementia in the Framingham Heart Study

Frontiers in Aging Neuroscience

Jeffrey S. Berger²  Nathanael R. Fillmore³  Nhan Do⁴  Ricardo S. Osorio⁵  Antonio Convit⁵  Babak A. Ardekani⁵  Ankit Parekh⁶  Rebecca A. Betensky⁷  Thomas M. Wisniewski⁸  Alexa Beiser^1,10  Joel Salinas^1,11  Zanetta Kovbasyuk^1,12  Omonigho M. Bubu^1,12  Sudha Seshadri^1,14  Andrew D. Johnson^1,16  Jaime Ramos-Cejudo^1,17  Chunlei Zheng^1,17 

[1] 0Division of Cardiology and Hematology, Department of Medicine, NYU Grossman School of Medicine, New York, NY, United States;1Center for the Prevention of Cardiovascular Disease, NYU Grossman School of Medicine, New York, NY, United States;2Harvard Medical School, Boston, MA, United States;3Boston University School of Medicine, Boston, MA, United States;4Nathan Kline Institute, Orangeburg, NY, United States;5Division of Pulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States;6Department of Biostatistics, New York University School of Global Public Health, New York, NY, United States;7Department of Pathology, NYU Grossman School of Medicine, New York, NY, United States;Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States;Department of Neurology, Boston University School of Medicine, Boston, MA, United States;Department of Neurology, Center for Cognitive Neurology, NYU Grossman School of Medicine, New York, NY, United States;Department of Psychiatry, New York University Grossman School of Medicine, New York, NY, United States;Division of Vascular Surgery, Department of Surgery, NYU Grossman School of Medicine, New York, NY, United States;Glenn Biggs Institute for Alzheimer’s and Neurodegenerative Diseases, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States;Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham, MA, United States;The Framingham Heart Study, Boston, MA, United States;VA Boston Cooperative Studies Program, MAVERIC, VA Boston Healthcare System, Boston, MA, United States;

关键词: Alzheimer’s disease;    dementia;    Framingham;    FHS;    neutrophil to lymphocyte ratio;    NLR;   

DOI  :  10.3389/fnagi.2021.773984

来源: DOAJ

【 摘 要 】

Objective: Active neutrophils are important contributors to Alzheimer’s disease (AD) pathology through the formation of capillary stalls that compromise cerebral blood flow (CBF) and through aberrant neutrophil signaling that advances disease progression. The neutrophil to lymphocyte ratio (NLR) is a proxy of neutrophil-mediated inflammation, and higher NLR is found in persons diagnosed with clinical AD. The objective of this study was to investigate whether increased NLR in older adults is independently associated with the risk of subsequent dementia.Methods: We examined associations of baseline NLR with incident dementia risk in the community-based Framingham Heart Study (FHS) longitudinal cohorts. The association between NLR and risk of dementia was evaluated using the cumulative incidence function (CIF) and inverse probability-weighted Cox proportional cause-specific hazards regression models, with adjustment for age, sex, body mass index (BMI), systolic and diastolic blood pressure, diabetes, current smoking status, low-density lipoprotein (LDH), high-density lipoprotein (LDL), total cholesterol, triglycerides, and history of cardiovascular disease (CVD). Random forest survival models were used to evaluate the relative predictive value of the model covariates on dementia risk.Results: The final study sample included 1,648 participants with FHS (average age, 69 years; 56% women). During follow-up (median, 5.9 years), we observed 51 cases of incident dementia, of which 41 were AD cases. Results from weighted models suggested that the NLR was independently associated with incident dementia, and it was preceded in predictive value only by age, history of CVD, and blood pressure at baseline.Conclusion: Our study shows that individuals with higher NLR are at a greater risk of subsequent dementia during a 5.9-year follow-up period. Further evaluating the role of neutrophil-mediated inflammation in AD progression may be warranted.

【 授权许可】

Unknown